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Colliec-Jouault, S., Esposito, F., Ledru, H., Sinquin, C., Marchand, L., Fillaudeau, A., Routier, S., Buron, F., Lopin-Bon, C., Cuenot, S., Bedini, E. & Zykwinska, A. (2023) Glycosaminoglycan Mimetics Obtained by Microwave-Assisted Sulfation of Marine Bacterium Sourced Infernan Exopolysaccharide. Biomacromolecules, 24 462–470.
Added by: Richard Baschera (2023-01-20 11:01:39) Last edited by: Richard Baschera (2023-01-20 11:02:23) |
| Type de référence: Article DOI: 10.1021/acs.biomac.2c01277 Numéro d'identification (ISBN etc.): 1525-7797 Clé BibTeX: ColliecJouault2023 Voir tous les détails bibliographiques  |
Catégories: INTERNATIONAL, PMN Créateurs: Bedini, Buron, Colliec-Jouault, Cuenot, Esposito, Fillaudeau, Ledru, Lopin-Bon, Marchand, Routier, Sinquin, Zykwinska Collection: Biomacromolecules |
Consultations : 22/146
Indice de consultation : 28% Indice de popularité : 7% |
| Liens URLs https://doi.org/10 ... acs.biomac.2c01277 |
| Résumé |
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Sulfated glycosaminoglycans (GAGs) are fundamental constituents of both the cell surface and extracellular matrix. By playing a key role in cell–cell and cell–matrix interactions, GAGs are involved in many physiological and pathological processes. To design GAG mimetics with similar therapeutic potential as the natural ones, the specific structural features, among them sulfate content, sulfation pattern, and chain length, should be considered. In the present study, we describe a sulfation method based on microwave radiation to obtain highly sulfated derivatives as GAG mimetics. The starting low-molecular-weight (LMW) derivative was prepared from the infernan exopolysaccharide, a highly branched naturally slightly sulfated heteropolysaccharide synthesized by the deep-sea hydrothermal vent bacterium Alteromonas infernus. LMW highly sulfated infernan derivatives obtained by conventional heating sulfation have already been shown to display GAG-mimetic properties. Here, the potential of microwave-assisted sulfation versus that of the conventional method to obtain GAG mimetics was explored. Structural analysis by NMR revealed that highly sulfated derivatives from the two methods shared similar structural features, emphasizing that microwave-assisted sulfation with a 12-fold shorter reaction time is as efficient as the classical one.
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Publisher: American Chemical Society
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