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Clavier, B., Baptiste, T., Massuyeau, F., Jouanneaux, A., Guiet, A., Boucher, F., Fernandez, V., Rogues, C. & Corbel, G. (2020) Enhanced bactericidal activity of brucite through partial copper substitution. J. Mat. Chem. B, 8 100–113.
Added by: Richard Baschera (2020-01-10 16:13:36) Last edited by: Richard Baschera (2020-01-14 09:11:26) |
| Type de référence: Article DOI: 10.1039/c9tb01927h Numéro d'identification (ISBN etc.): 2050-750X Clé BibTeX: Clavier2020 Voir tous les détails bibliographiques  |
Catégories: IMN Mots-clés: antibacterial activity, cuo, hydration, ion, kinetics, magnesium-oxide, mechanism, mgo, nanoparticles, spectra Créateurs: Baptiste, Boucher, Clavier, Corbel, Fernandez, Guiet, Jouanneaux, Massuyeau, Rogues Collection: J. Mat. Chem. B |
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Brucite Mg(OH)(2) belongs to a family of two-dimensional compounds with a CdI2-type structure built up from layers of edge-sharing octahedra delineating 2D galleries. In the current study, nanometer-sized platelets of copper substituted Mg(OH)(2) were prepared by co-precipitation at room temperature in mixed alkaline (NaOH/Na2CO3) medium. Very weak substitution of a few hydroxyl ions by carbonate groups was highlighted at first by infrared spectroscopy and then quantified by thermogravimetric (TG) and mass spectrometric (MS) evolved gas analyses. The presence in a very low amount of water molecules in the galleries induces disorder in the stacking of layers of edge-sharing octahedra along the c-axis. The dehydration of the hydroxides taking place below 225 degrees C preserves the brucite-type structure of the samples while suppressing the stacking disorder. Copper substitution greatly enhances the bactericidal activity of nanometer-sized platelets of brucite against two bacteria frequently involved in healthcare-associated-infections. 10 mol% of cupric ions in Mg(OH)(2) (a copper loading of 0.102 mg mL(-1) in the suspension) were sufficient to induce, after 3 h in contact, 100% and 99.3% reductions in viability of Gram-negative E. coli and Gram-positive S. aureus, respectively (reductions as low as 23% and 48% are reported for the parent compound Mg(OH)(2) in the same conditions). A good compromise between fast bactericidal kinetics and a high reduction in viability is reached by the 15 mol% copper-substituted Mg(OH)(2) hydroxide. Its use gives the opportunity to five-fold reduce the copper loading of the bactericidal agent while being at least equally or even more efficient compared to the conventional CuO (a Cu loading of 0.799 mg mL(-1) and 0.154 mg mL(-1) in the suspension of CuO and 15 mol% copper substituted Mg(OH)(2) particles, respectively).
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