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Hidalgo, T., Cooper, L., Gorman, M., Lozano-Fernandez, T., Simon-Vazquez, R., Mouchaham, G., Marrot, J., Guillou, N., Serre, C., Fertey, P., Gonzalez-Fernandez, A., Devic, T. & Horcajada, P. (2017) Crystal structure dependent in vitro antioxidant activity of biocompatible calcium gallate MOFs. J. Mat. Chem. B, 5 2813–2822.
Added by: Richard Baschera (2017-05-05 13:45:22) Last edited by: Richard Baschera (2017-05-05 13:49:30) |
| Type de référence: Article DOI: 10.1039/c6tb03101c Numéro d'identification (ISBN etc.): 2050-750X Clé BibTeX: Hidalgo2017 Voir tous les détails bibliographiques  |
Catégories: INTERNATIONAL, ST2E Mots-clés: apoptosis detection, biomolecules, complexes, cytotoxicity, drug-delivery, gallic acid, metal-organic frameworks, nanoparticles, phenolic-compounds, products Créateurs: Cooper, Devic, Fertey, Gonzalez-Fernandez, Gorman, Guillou, Hidalgo, Horcajada, Lozano-Fernandez, Marrot, Mouchaham, Serre, Simon-Vazquez Collection: J. Mat. Chem. B |
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Two novel 3-D coordination polymers, denoted MIL-155 and MIL-156 (MIL stands for Materials Institute Lavoisier), built up from calcium and the naturally occurring gallic acid (H4gal), have been hydrothermally synthesized and their crystal structures were determined by single-crystal X-ray diffraction. These solids are based on different inorganic subunits: infinite chains of edge-sharing dimers of CaO7 polyhedra linked through partially deprotonated gallate ligands (H(2)gal(2-)) for MIL-155 or [Ca-2(H2O)(H(2)gal)(2)]center dot 2H(2)O, and ribbon-like inorganic subunits containing both eight-fold or six-fold coordinated Ca-II ions linked through fully deprotonated gallate ligands (gal(4-)) for MIL-156 or [Ca3K2(H2O)(2)(gal)(2)]center dot nH(2)O (n similar to 5). Both solids contain small channels filled with water molecules, with, however no accessible porosity towards N-2 at 77 K. MIL-155 and MIL-156 were proven to be biocompatible, as evidenced by in vitro assays (viability and cell proliferation/death balance). While the high chemical stability of MIL-156 makes it almost bioinert, the progressive degradation of MIL-155 leads to an important protective antioxidant effect, associated with the release of the bioactive gallate ligand.
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