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Lavenus, S., Trichet, V., Le Chevalier, S., Hoornaert, A., Louarn, G. & Layrolle, P. (2012) Cell differentiation and osseointegration influenced by nanoscale anodized titanium surfaces. Nanomedicine, 7 967–980.
Added by: Laurent Cournède (2016-03-10 21:28:39) |
| Type de référence: Article DOI: 10.2217/NNM.11.181 Numéro d'identification (ISBN etc.): 1743-5889 Clé BibTeX: Lavenus2012 Voir tous les détails bibliographiques  |
Catégories: PMN Mots-clés: anodized titanium, behavior, bone bonding strength, bone response, bone-to-implant contact, iii collagen, implants, in-vitro, matrix protein comp, mechanical strain, Mesenchymal stem cells, mesenchymal stem-cells, nanostructured surfaces, Osteoblasts, osteogenic differentiation, tio2 nanotubes Créateurs: Hoornaert, Lavenus, Layrolle, Le Chevalier, Louarn, Trichet Collection: Nanomedicine |
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Aims: We aimed to study the interactions between human mesenchymal stem cells and the bone integration of nanostructured titanium implants. Materials \& methods: Nanopores of 20, 30 and 50 nm were prepared by anodization of titanium at 5, 10 and 20 V in a mixture of fluorhydric and acetic acid. Ti 30 and 50 nanostructures promoted early osteoblastic gene differentiation of the human mesenchymal stem cells without osteogenic supplements. The osseointegration of nanostructured and control titanium implants was compared by implantation in rat tibias for 1 and 3 weeks. Results: The nanostructures significantly accelerated bone apposition and bone bonding strength in vivo in correlation with in vitro results. Conclusion: These findings demonstrate that specific nanostructures controlled the differentiation of cells and, thus, the integration of implants in tissues. These nanoporous titanium surfaces may be of considerable interest for dental and orthopedic implants.
Added by: Laurent Cournède |