Hoang, S., Olivier, S., Cuenot, S., Montillet, A., Bellettre, J. & Ishow, E. (2020) Microfluidic Assisted Flash Precipitation of Photocrosslinkable Fluorescent Organic Nanoparticles for Fine Size Tuning and Enhanced Photoinduced Processes. ChemPhysChem, 21 2502–2515.
Added by: Richard Baschera (2020-11-17 13:20:19) Last edited by: Richard Baschera (2021-03-23 08:42:27)
|Type de référence: Article
Numéro d'identification (ISBN etc.): 1439-4235, 1439-7641
Clé BibTeX: Hoang2020
Voir tous les détails bibliographiques
|Catégories: INTERNATIONAL, PMN
Créateurs: Bellettre, Cuenot, Hoang, Ishow, Montillet, Olivier
Consultations : 5/76
Indice de consultation : 8%
Indice de popularité : 2%
|Liens URLs https://onlinelibr ... 002/cphc.202000633|
Highly concentrated dispersions of fluorescent organic nanoparticles (FONs), broadly used for optical tracking, bioimaging and drug delivery monitoring, are obtained using a newly designed micromixer chamber involving high impacting flows. Fine size tuning and narrow size distributions are easily obtained by varying independently the flow rates of the injected fluids and the concentration of the dye stock solution. The flash nanoprecipitation process employed herein is successfully applied to the fabrication of bicomposite FONs designed to allow energy transfer. Considerable enhancement of the emission signal of the energy acceptors is promoted and its origin is found to result from polarity rather than steric effects. Finally, we exploit the high spatial confinement encountered in FONs and their ability to encapsulate hydrophobic photosensitizers to induce photocrosslinking. An increase in the photocrosslinked FON stiffness is evidenced by measuring the elastic modulus at the nanoscale using atomic force microscopy. These results pave the way toward the straightforward fabrication of multifunctional and mechanically photoswitchable FONs, opening novel opportunities in sensing, multimodal imaging, and theranostics. © 2020 Wiley-VCH GmbH.