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Kama, A. B., Jeanneau, E., Sidibe, M., Diop, C. A. K. & Gautier, R. (2019) Cocrystallization through the use of a salt: The case of thiourea with a new propanediammonium oxalate salt. J. Cryst. Growth, 528 UNSP 125267.
Added by: Richard Baschera (2019-11-22 13:17:49) Last edited by: Richard Baschera (2019-11-22 13:19:17) |
| Type de référence: Article DOI: 10.1016/j.jcrysgro.2019.125267 Numéro d'identification (ISBN etc.): 0022-0248 Clé BibTeX: Kama2019a Voir tous les détails bibliographiques  |
Catégories: INTERNATIONAL, MIOPS Mots-clés: acid, co-crystals, Cocrystal, crystal structure, Growth from solutions, monohydrate, organic compounds, polymorphs, X-ray diffraction Créateurs: Diop, Gautier, Jeanneau, Kama, Sidibe Collection: J. Cryst. Growth |
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Selecting molecules with functional groups such as NH and CO can facilitate the growth of cocrystals through the creation of hydrogen bond networks. However, some compounds such as oxalic acid and thiourea, yet having such functional groups, do not cocrystallize. In this paper, we show that the prior formation of salts combining the oxalic acid with a strong amine (high Delta pka) can help enhancing the electronic density of the hydrogen bond acceptor (CO groups). Using the resulting salt with thiourea can, then, lead to a cocrystal. This phenomenon is illustrated with the synthesis of a new compound (C3H12N2)(2)(C2O4)(2)center dot CH4N2S by cocrystallization of a new propanediammonium oxalate salt and thiourea. The salt and cocrystal were structurally characterized by powder and single crystal X-ray diffraction, and FT-IR spectroscopy was used to rationalize the hydrogen bonding.
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