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Desigaux, L., Ben Belkacem, M., Richard, P., Cellier, J., Leone, P., Cario, L., Leroux, F., Taviot-Gueho, C. & Pitard, B. (2006) Self-assembly and characterization of layered double hydroxide/DNA hybrids. Nano Lett. 6 199–204.
Added by: Florent Boucher (2016-05-12 13:21:38) |
| Type de référence: Article DOI: 10.1021/nl052020a Numéro d'identification (ISBN etc.): 1530-6984 Clé BibTeX: Desigaux2006 Voir tous les détails bibliographiques  |
Catégories: CESES Mots-clés: cationic lipids, dna, gene delivery Créateurs: Ben Belkacem, Cario, Cellier, Desigaux, Leone, Leroux, Pitard, Richard, Taviot-Gueho Collection: Nano Lett. |
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| Résumé |
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The purpose of this study was to control the fabrication of new labile supramolecular assemblies by formulating associations of DNA molecules with inorganic layered double hydroxides (LDHs). The results show that LDH/DNA hybrids synthesized by a coprecipitation route involving the in situ formation of LDHs around DNA molecules acting as templates were characterized by a lamellar organization, with DNA molecules sandwiched between hydroxide layers, exhibiting a regular spacing of 1.96 nm. Our results indicate that labile complexes resulting from the association of nucleic acids and inorganic materials can be obtained not only by anion exchange but also by a direct self-assembly route.
Added by: Florent Boucher |