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Ranaivondrambola, T., Hatton, W., Felpin, F.-X., Evain, M., Mathe-Allainmat, M. & Lebreton, J. (2010) Synthesis of a Racemic Nicotine-Lobeline Hybrid. Synlett, 1631–1634.
Added by: Laurent Cournède (2016-03-10 21:37:32) |
| Type de référence: Article DOI: 10.1055/s-0029-1219966 Numéro d'identification (ISBN etc.): 0936-5214 Clé BibTeX: Ranaivondrambola2010 Voir tous les détails bibliographiques  |
Catégories: MIOPS Mots-clés: 1st total-synthesis, acetylcholine-receptors, alkaloids, allylation, analogs, binding protein, chiral imines, drug discovery, neuronal nicotinic acetylcholine receptors, pyrrolidine, ring-closing metathesis, Total synthesis Créateurs: Evain, Felpin, Hatton, Lebreton, Mathe-Allainmat, Ranaivondrambola Collection: Synlett |
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| Résumé |
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The first synthesis of a racemic nicotine-lobeline hybrid is described based on a diastereoselective allylation and an RCM reaction as key steps. This synthetic route paves the way to the preparation of original potential ligands of nAChRs.
Added by: Laurent Cournède |